克罗米酚对男性极低促性腺素性功能减退症有效

纽约（美联社肥胖英文版）1月底四日华盛顿邮报：据发表在12月底年出英文版的《受孕与不育》杂志的一项分析报告认为克罗米酮类对之外高于促性腺素性功能有所增加的男性高血压有利。来自伯明翰阿拉巴马所学校的该分析报告的第一作者Scott J. Whitten芝加哥所学校在给与路透通讯社采访问道：“原发性或则否HH高血压在给与侵害性大得多和更为昂贵的病患（例如施用促性腺激素类）前来进行4个月底的克罗米酮类在在病患是有利的。”Whitten芝加哥所学校和朋友研究了克罗米酮类对10名HH男性高血压（HH是导致男性不育的罕有因素）是否直接。分析报告称克罗米酮类病患1年后，4名卡尔曼(氏)综合征高血压中只有一名高血压的胚胎pH增加而全肾上腺功能有所增加症高血压的胚胎缺乏病因均没得不到优化。相反，该分析报告认为3名未成年发作的原发性HH男性高血压经过3个月底克罗米酮类的病患胚胎pH有了明显增加。目前为止该组高血压仅有两名恢复了后生。Whitten芝加哥所学校说：“除非对克罗米酮类病患没反应，我们不会因为副作用停止对高血压用作该药品。”最后作者归纳说：“因为条件极少，对HH高血压促性腺激素苯和克罗米酮类的随机研究难以来进行，然而利用多系列的严格选择标准对高血压来进行基准可能帮助进一步可验证克罗米酮类恢复男性高于后生的直接性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

出英文版人：橙色幻想

出英文版人： 张靖